WONDER

Built from Her Own Cells

Friday, April 3, 2026

Built from Her Own Cells

Great Ormond Street Hospital · https://www.gosh.nhs.uk/news/gosh-surgeon-paolo-de-coppi-makes-first-time100-health-list/

Scientists grew a functioning esophagus from a recipient's own stem cells. It could soon help children who cannot swallow.

What's happening

Scientists at University College London and Great Ormond Street Hospital published results in Nature Biotechnology showing the first successful implantation of lab-grown esophagi in animals. The team took small samples of muscle cells from recipient pigs, cultivated two types of stem cell, and grew them on donor scaffolds over two months. Surgeons then replaced 2.5-centimetre segments of esophagus with the engineered grafts. Five of eight pigs survived the full six-month study, developing functional muscle, nerves, and blood vessels. The technique targets children born with esophageal atresia, a condition affecting 1 in 4,167 births in which a gap in the esophagus prevents swallowing. Current treatment requires moving the child's stomach to the neck. Paediatric surgeon Paolo De Coppi says clinical use may be possible within five years.

What the text says

Mark 7:34-3734Looking up to heaven, he sighed, and said to him, "Ephphatha!" that is, "Be opened!"35Immediately his ears were opened, and the impediment of his tongue was released, and he spoke clearly.36He commanded them that they should tell no one, but the more he commanded them, so much the more widely they proclaimed it.37They were astonished beyond measure, saying, "He has done all things well. He makes even the deaf hear, and the mute speak!"

Jesus looked up, sighed, and said Ephphatha: "Be opened." The man who could not speak properly began to speak plainly. The crowd's response was specific: "He has done everything well. He even makes the deaf hear and the mute speak." The Greek word kalos, translated "well," means beautifully, rightly, as it should be. The crowd is not just impressed by the power. They are struck by the rightness of it. A body was missing something, and now it is whole.

Mark records that Jesus sighed before healing. The Greek stenazo is the same word Paul uses in Romans 8 for creation groaning. The sigh is not fatigue. It is the weight of encountering a body that is not yet what it was made to be. The healing is one of several moments in the Gospels where restoration of the body is presented as evidence that something true about creation is being revealed.

The reflection

A team of surgeons taking cells from a child's own body, growing them for two months on a scaffold, and rebuilding the organ that lets her eat is not the same as a miracle in Galilee. No one is claiming it is. What the text offers is a framework for recognizing what the scientists are doing: restoring a body to the function it was made for. The sigh Jesus breathes before healing suggests that God is not indifferent to the body's incompleteness. Five pigs that can swallow are not the end of the story. They are the scaffold.

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